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2018 - Issue 3
IS-MPMI > COMMUNITY > Interactions > Categories
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2018's third issue of IS-MPMI Interactions includes a letter from IS-MPMI President Regine Kahmann and IS-MPMI members who received awards at ICPP2018.
IS-MPMI President Regine Kahmann previews the IS-MPMI XVIII Congress in Glasgow and recaps this year at IS-MPMI.
IS-MPMI member Pierre de Wit is the 2018 recipient of the Jakob Eriksson Prize, awarded by the International Society of Plant Pathology at the International Congress of Plant Pathology (ICPP2018). The Eriksson Prize is the highest international honor for achievement in plant pathology. Read an interview with de Wit and find out how to watch his lecture online!
Four IS-MPMI Members Receive APS Awards at ICPP2018
Melania Figueroa, Howard S. Judelson, Barbara S. Valent, and Xueping Zhou received awards at ICPP2018. Read about their distinguished careers!
News
Job Openings
IS-MPMI Interactions |
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Editor-in-Chief: Dennis Halterman Staff Editor: Michelle Bjerkness |
The deadline for submitting items to the next issue of Interactions is February 23, 2018. |
IS-MPMI Interactions is a quarterly publication by the International Society of Molecular Plant-Microbe Interactions 3340 Pilot Knob Rd. • St. Paul, MN 55121 Phone: +1.651.454.7250 • Fax: +1.651.454.0766 E-mail: IS-MPMI HQ Web: www.ismpmi.org |
Share views on "hot topics," anecdotal stories about research findings published in the MPMI journal, or science-related events within the community. E-mail Dennis Halterman or submit items online. |
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| Two
years have passed since the highly successful and scientifically stimulating XVII
International Congress on Molecular Plant-Microbe Interactions in Portland in
2016, and it is almost 1 more year to go until IS-MPMI XVIII convenes in
Glasgow, Scotland, on July 14–18, 2019. This long period makes you wonder what
IS-MPMI and the board of directors have been doing since 2016.
This year’s
efforts of the board of directors have been largely devoted to organizing the
2019 congress in Glasgow together with the local organizers, Paul Birch and
John Jones, and the local organizing committee, representing all areas of
IS-MPMI in the UK. We have decided in several sessions on the plenary speakers
and the chairs of concurrent sessions. The goal has been to generate a mix of
established and junior speakers with broad international representation and a
good gender balance. Looking at the program, I think we have largely achieved
this. It has also been very rewarding to hear that almost without exception,
all the invited scientists have agreed to speak. I am also very happy to let
you know that the financial situation of our society is such that we will be
able to grant travel support to more junior scientists to attend the 2019 congress
in Glasgow. The website to apply for this funding will open in early 2019.
When
I took over the presidency from Sheng Yang He in Portland, it was time to
restructure the IS-MPMI Interactions
platform—our forum to communicate with you. I felt that we should not miss out
on the immense expertise of outstanding members of our society who have
recently retired. It’s my great pleasure to report that Fred Ausubel, Paola
Bonfante, Alan Colmer, Allan Downie, and Dan Klessig readily agreed to my
inquiry and will from now on form a team of senior advisors for Interactions that the editor-in-chief can
turn to for advice. Brad Day stepped down as editor-in-chief of Interactions, and Dennis Halterman enthusiastically
took over the position and is breaking new ground by soliciting participation
in particular of our younger members, who among other things have chosen
eminent scientists for interviews. I still see room for improvement, i.e., more
participation of our members. It would be great if you would tell us the topics
you would like to see printed and discussed so that we can focus our efforts on
content that matters to our members, in particular the junior members, to keep
them excited about science and engaged in our society.
IS-MPMI
is a truly international society, and we currently have about 1,000 members
from 43 countries. I would be very happy to see more participation by members
from all countries with respect to engagement in our society. IS-MPMI is an
open society, and views and suggestions from all members are welcome. We would
like to communicate with our members, and we appreciate your suggestions on how
best to accomplish this goal, especially career advancement for our young
members. We desire to foster a strong sense of community.
MPMI, the dedicated journal of our society, has been
running smoothly under the expert guidance of John McDowell as editor-in-chief.
John has made substantial efforts, together with his editorial team, to
increase the visibility of MPMI
during difficult times, in which more and more journals are launched and
compete for papers. His 3-year term will end in December 2018, and we are happy
to announce that Jeanne Harris will take over then. Let me take the opportunity
to thank John for all of his time and effort devoted to MPMI. Let me also take the opportunity to thank members of the board
of directors for their extremely valuable input during the many calls and for
their willingness to take on responsibility for IS-MPMI affairs and advancing
the functioning of our society. And a big thank-you to the staff for keeping
our input into the daily affairs of the society to a minimum.
With
respect to our science, I sense that times are changing: Model systems will certainly
continue to be of enormous value by elucidating the basic mechanisms of how
microbes interact with plants. When I attended my first IS-MPMI meeting in
Interlaken in 1990, I was incredibly proud to be allowed to talk about a system
that seemed odd at the time but since has become a model for biotrophic fungal–plant
interactions. I find it truly rewarding that it has survived and flourished for
three decades and continues to deliver unprecedented and exciting insights.
Such models are important and will continue to be so. However, with the advent
of new technologies, even difficult-to-handle systems of considerable
importance in agriculture are becoming tractable. We should return to these: obligate
and emerging pathogens, obligate symbionts, and the transplantation of entire
systems, such as nitrogen fixation, into crop plants.
As I write this letter, I am on vacation in my summerhouse
at the Baltic Sea. It is one of the driest summers on record, and it is
horrifying to see plants getting weak first due to the drought and then
succumbing to pathogens. Watching this happen not just in your own garden but
also in the neighboring fields tells you that the importance of our work will
grow if we want to solve worldwide problems of crop production under changing
climate conditions. We need to improve plant productivity and contribute to a
sustainable agriculture. The engineering of broad-spectrum and durable resistance
continues to be one of the big future challenges. The availability of genome
information of the most important crop species, together with modern genome
engineering techniques, is expected to spur new initiatives in this direction. Another
hurdle I see is that most of our results are obtained and validated in
controlled laboratory settings. In most cases, we do not know to what extent traits
we have introduced will work out under field conditions, where plants may be
exposed not to one but to several threats simultaneously or in succession
and/or to slowly changing environments, involving several factors. In this regard,
it is shocking that in July 2018, the Court of Justice of the European Union
has ruled that gene-edited crops should be subject to the same regulations that
are applied to conventional genetically modified organisms—even if they do not
contain transgenes. This is a severe blow to the more translational research in
our field in all of Europe. I can only hope that those of you who are affected
by this ruling will not give up your fight against it.
I will end with a personal note: In one of his letters
to you, Sheng Yang He, previous president of our society, voiced that he feels unsatisfied
to witness young group leaders struggle to find a new niche and he suggested
several solutions. I agree with him that this continues to be a problem. But I
see an even deeper problem developing in science in general: Doing science may
lose some of its attraction. For me throughout my scientific career, doing
science, i.e., solving a scientific problem that you have picked yourself, has
been immense fun and highly rewarding. I see this at stake not while you work
on solving the problem but when you try to publish it. Our publishing culture,
in my view, has eroded to a point that it becomes increasingly impossible to
publish exciting new findings quickly, because you are asked to add more and
more detail during several rounds of revision, which delays publication to an
unacceptable length. Let me make clear that I am not talking about missing
controls and/or flaws in the data but about an almost deliberate delay by the
reviewers—who are our colleagues. I am afraid that such experiences will
seriously damage the interest in basic research and may turn away our most
promising young PhDs and post-docs from pursuing a scientific career. We will
pick up this discussion with the board of directors and the IS-MPMI community
to meet this challenge and develop an effective strategy, because the future also
of our scientific field critically depends on the young scientists and their
excitement, engagement, and fun in doing science and tackling the unknown.
I am very much looking forward to seeing many of you
in Glasgow next year.
Best wishes,
Regine Kahmann, President
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| IS-MPMI member Pierre de Wit is the 2018 recipient
of the Jakob Eriksson Prize, awarded by the International Society of Plant
Pathology at the International Congress of Plant Pathology (ICPP2018). The
Eriksson Prize is the highest international honor for achievement in plant
pathology. Established in 1923, the prize encourages creative study of plant
pathogens and the processes of disease development in plants. The prize is
named for Jakob Eriksson (1848–1931), a prominent Swedish mycologist and plant
pathologist who was an international leader. The prize was first awarded in
1930 and has since been awarded to 11 individuals from seven countries.
de Wit has been a pioneer in molecular plant pathology and plant–microbe interactions research. Among his many accomplishments, he was instrumental in introducing molecular biology techniques into phytopathology research. He has authored or co-authored close to 200 articles, several of which have been published in high-impact scientific journals. de Wit is also an elected member of the Royal Netherlands Academy of Arts and Sciences and received the Academy Professor Prize in 2008, the Emil Christian Hansen Gold Medal Award from the Carlsberg Foundation in 1996, and the Noel Keen Award from The American Phytopathological Society in 2007.
A recording of de Wit’s lecture at ICPP2018 is available online.
What area(s)
of molecular plant–microbe interactions do you feel your research has impacted
most?
As an MSc
student at Wageningen University in the 1970s, I was intrigued by lectures on the
gene-for-gene hypothesis proposed in the 1940s by Professor Oort in the
Netherlands for wheat and Ustilago
tritici and by Harold Flor in the U.S.A. for flax and Melampsora lini. I was fortunate to be offered a PhD position and having
the freedom to choose my own research subject. I ended up studying the
interaction between tomato and Cladosporium
fulvum. I witnessed different episodes in the research on gene-for-gene
systems. At the third ICPP in Munich in 1978—the first international congress
that I attended—research was focused on elicitors and their capacity to more
quickly induce phytoalexins in incompatible interactions than in compatible
ones. My role models at that congress were Noël Keen, Peter Albersheim, and
Joseph Kuć. Their research inspired me to carry on in times when I did not make
much progress in my own research. Phytoalexins have now become popular as health-enhancing
phytochemicals (such as resveratrol, glyceollin, polyphenols, etc.). I was
surprised to read an article recently that the tomato phytoalexin falcarindiol,
which we discovered in tomato in 1981, is also a potential drug, inhibiting
human cancer cell lines. In addition to phytoalexins, we studied the role of
antifungal pathogenesis-related proteins, including chitinases and β-1,3-glucanases
in incompatible interactions. However, the breakthrough came when we started to
study apoplastic fluids from tomato leaves infected by C. fulvum, which appeared to contain many proteinaceous elicitors—the
products of fungal avirulence (Avr) genes
recognized by cognate Cf receptor-like proteins in tomato. Then, very soon, the
specificity question was solved. In the absence of cognate Cf-proteins,
race-specific elicitors (now called “effectors”) suppress defense responses
induced by nonspecific (glyco) protein fungal elicitors (now called “pathogen-associated
molecular patterns,” or PAMPs), and in the presence of cognate Cf proteins,
they induce a Cf-mediated defense response. With a very enthusiastic group of
MSc students, PhD students, and post-docs, we have cloned many C. fulvum effectors, and for some of them,
the structure and function have been elucidated. Many of the PhD students and
post-docs now occupy prestigious academic positions, and I see the Jakob
Eriksson Prize also as a recognition of their contributions to my research.
What
advice do you have for young scientists aspiring to achieve the level of
science that has major impact?
There is
no guidebook that leads to success in science. Everybody stands on the
shoulders of other scientists who have pioneered and partly paved roads in
different research directions. There are still many fundamental and applied
research questions in plant–microbe interactions that need to be addressed and
solved in order to get more sustainable agriculture. I grew up on a farm and
was motivated to find alternatives for the use of pesticides after reading the
book Silent Spring, written by Rachel
Carson in 1962. I still strongly believe in the power of disease resistance
breeding in sustainable agriculture together with healthy soils and biocontrol
agents when no resistance genes are available. The genomics era opens new ways
to address and solve difficult research questions. However, to become
successful in science, talent is not enough; ambition, curiosity, inspiration, loving
your work, endurance, and not being afraid of working hard and making mistakes
are equally important. However, it is also important to get sufficient time to
develop a new research line after your PhD, which is not easy, as tenure
positions are becoming rare in many countries.
When you
were a post-doc, what had the largest influence on your decision to enter your
specific research area in your permanent position? Was this a “hot topic” at
the time, or did you choose to go in a different direction?
I was
very fortunate to obtain a permanent position already during my PhD, as I was
hired to assist in teaching and work on my PhD project. This gave me more time
to develop my PhD project than a regular PhD student. If I had been allowed to
work on my PhD project for only 4 years, I would never have discovered the race-specific
elicitors of C. fulvum and their encoding
genes. After my PhD, I received a Fulbright Fellowship to work 1 year in the U.S.A.
in the laboratory of Professor Joseph Kuć at the University of Kentucky in
Lexington, which allowed me to continue my research project and interact with
researchers working on induced systemic resistance against pathogens in
different crops. At that time, research on gene-for-gene interactions was a hot
topic, as well as research on local and systemic resistance, and they still are.
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| Melania
Figueroa, University of Minnesota, is the 2018 recipient of the APS Syngenta
Award. This award is given by Syngenta Crop Protection to an APS member for an
outstanding recent contribution to teaching, research, or extension in plant
pathology. Priority for this award is given to APS members who are in the first
decade of a career in plant pathology.
|
Melania Figueroa, second from left, receives the APS Syngenta Award at ICPP2018 |
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What area(s) of
molecular plant–microbe interactions do you feel your research has impacted
most?
I feel that my research has
influenced two areas: first in nonhost resistance, and second in understanding
the genomics of complex pathogens. As a post-doc, I started developing Brachypodium distachyon as a system to
understand the boundaries of plant susceptibility to Puccinia graminis f. sp. tritici
(wheat stem rust). Rust fungi pose a significant constraint to the production
of small grains, such as wheat, barley, and oat. The potential to utilize this fungal
species to engineer disease resistance to rust and define the molecular
mechanisms that dictate whether a plant will serve as a host is fascinating.
Through this work, I have had the pleasure to work with a network of scientists
who have made important contributions in developing genetic and genomic
resources in B. distachyon to enable
studies like those pursued in my laboratory. As an assistant professor, I have
since worked on decoding the complex genomes of rust fungi, which are
dikaryotic organisms and possess two quite diverse nuclear genomes. I have had
the opportunity to direct my group to address critical challenges to generate
genome references for rust fungi that allow comparisons of both nuclei. This
work has been crucial to understanding the genetic diversity between both
haplotypes, which has important implications for the evolution of virulence. In
this research area, I have been very fortunate to work excellent scientists to
discover the first effector gene in a cereal rust.
What advice do you have
for young scientists aspiring to achieve the level of science that has major
impact?
An important step to achieve impactful science is first to
identify an area of research that addresses a real gap in understanding and can
change the way we think or deliver a solution to a problem that affects many of
us. I also believe it is important that we are truly passionate about our work,
so choose a topic that really interests you. Curiosity, creativity, and
persistence are essential qualities. We should always remember that there is always
a way to test a hypothesis; it is just a matter of finding how and being open-minded
about alternative possibilities. We
should always let the science be our guide. I advise young scientists to not be
afraid or ashamed to ask for help when needed. Surround yourself with
collaborators with whom you can have fun. The bonds you build with them will
provide you with support if you ever feel discouraged.
When you were a post-doc,
what had the largest influence on your decision to enter your specific research
area in your permanent position? Was this a “hot topic” at the time, or did you
choose to go in a different direction?
My decision to enter my current areas
of research was not influenced by a “hot topic.” I simply wished to learn more
about the systems I was studying as a post-doc. I recognized that there was a
lot to be done and was ready to move on to the next step in my career to
achieve these goals. Since I started my position as an assistant professor, my
research program has grown to areas I would have never predicted. Every day I
learn something new (well…almost every day).
|
| Howard
S. Judelson, University of California at Riverside, is a 2018 Fellow of The
American Phytopathological Society (APS). This honor recognizes distinguished
contributions to plant pathology in one or more of the following areas:
original research, teaching, administration, professional and public service,
and extension and outreach.
Howard S. Judelson, center, receives the APS Fellow Award at ICPP2018 |
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What area(s) of molecular
plant–microbe interactions do you feel your research has impacted most?
When
I started my post-doctoral position, molecular research on oomycetes was in a
rather primitive state. No one had even cloned or sequenced a single gene! At
the time, people were just starting to realize that oomycetes were not true
fungi. My work on developing tools for the molecular manipulation of oomycetes
helped show that progress could be made on these “difficult” species, which
encouraged others to enter the field.
What advice do you have for
young scientists aspiring to achieve the level of science that has major
impact?
Pick
something that you are passionate about, and then stick with it (within
reason). While some exciting results come quickly in research, many important
findings come through the aggregation of multiple incremental advances in
knowledge or methods. Do not be afraid to pick a topic that no one has investigated
before. Think and read widely, and attend seminars both inside and outside your
discipline, since you might find something that could be applied to your own
work.
When you were a post-doc,
what had the largest influence on your decision to enter your specific research
area in your permanent position? Was this a “hot topic” at the time, or did you
choose to go in a different direction?
While
my current research deals mostly with Phytophthora
infestans, most of my post-doctoral work focused on another oomycete. I was
fortunate that my post-doctoral advisor (Richard Michelmore) gave me the
freedom to start a side project on P.
infestans. This was definitely not a hot topic; barely a handful of
laboratories in the entire world were studying any aspect of oomycete molecular
biology at the time. As an undergraduate, I was fascinated by the elegant
illustrations of oomycete life cycles in the Plant Pathology text written by George Agrios. When I became a post-doc,
I saw the opportunity to apply my interest in microbial development to a field
with practical impact, such as plant pathology.
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| Barbara
S. Valent, Kansas State University (KSU), is the 2018 winner of the APS Noel T.
Keen Award. The Keen Award recognizes research excellence in molecular plant
pathology. Nominees have made outstanding contributions and demonstrated
sustained excellence and leadership in research that significantly advances the
understanding of molecular aspects of host–pathogen interactions, plant
pathogens or plant-associated microbes, or molecular biology of disease
development or defense mechanisms.
Dr. Valent
received her BA degree in chemistry in 1972 and her PhD in biochemistry in 1978
from the University of Colorado at Boulder. Following post-doctoral work at
Cornell University and the University of Colorado, she began her research
career as a principal investigator in molecular plant pathology in 1985 at
DuPont Central Research and Development in Delaware. She was promoted to the
position of research leader in 1992, to research manager of the Plant and
Fungal Genetics and Molecular Biology Program in 1994, and to research fellow
and technical leader of the Genetic Disease Resistance Program of DuPont
Agricultural Products in 1997. Dr. Valent was appointed as a professor in the
Department of Plant Pathology at KSU in 2001. In 2002, she was designated a
university distinguished professor, and in 2004, she was appointed chair of the
Interdepartmental Genetics Program at KSU.
Dr. Valent
has made outstanding and fundamental contributions in the field of plant
pathology. More than 20 years ago, she recognized the need for a
well-characterized and easily manipulated model system to understand how plants
and fungi interact to ultimately lead to disease or resistance. She proposed
and developed Magnaporthe grisea, the rice blast fungus, to serve as
such a model. Because of her efforts, this pathogen is now one of the most
extensively studied and important fungal models for molecular genetic and
biochemical analyses of plant–fungal interactions. Using this research tool as
her base, Dr. Valent has been at the forefront of several fundamental areas. She
was the first to identify and clone both a blast fungal gene that controls the
induction of resistance in plants (Avr gene) and the corresponding gene
from rice (R gene) that is involved in recognition of the fungal gene.
She was the first to demonstrate for this class of R gene that the AVR
and R gene products physically interact and that this interaction likely
occurs inside living plant cells. These are exciting findings with huge
implications for transduction of the signals that result in plant resistance.
Dr. Valent’s many profound
insights have also had important practical applications. While elucidating how
fungal pathogens adhere to and penetrate host plants, which involved the
genetic dissection of melanin biosynthesis in M. grisea, she and her
colleagues discovered different possible targets for chemical control of fungal
diseases and also a powerful fungal adhesive that even sticks to Teflon! This
adhesive was later patented. Based on findings using molecular markers for
analysis of M. grisea population structure over wide geographic
areas, she and her collaborators have fundamentally changed the strategies
plant breeders use to deploy resistance to this important disease. Molecular
markers corresponding to the R gene cloned in her laboratory have also
been valuable, because this gene confers resistance to the major pathotypes of
the fungus in the United States. Thus, Dr. Valent’s basic research has had huge
implications for practical disease control.
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| Xueping
Zhou, Chinese Academy of Agricultural Sciences, is a 2018 Fellow of The
American Phytopathological Society (APS). This honor recognizes distinguished
contributions to plant pathology in one or more of the following areas: original
research, teaching, administration, professional and public service, and
extension and outreach.
|
Xueping Zhou, center, receives the APS Fellow Award at ICPP2018 |
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What area(s) of molecular
plant–microbe interactions do you feel your research has impacted most?
Our
work mainly focused on plant–virus interaction using geminiviruses. We revealed
that βC1, encoded by a geminivirus satellite, is a symptom determinant, a
repressor of transcriptional gene silencing (TGS) and post-transcriptional gene
silencing (PTGS), and also a target of many plant defense responses, including
phosphorylation modifications-mediated function suppression and ubiquitin
proteasome system (UPS) and autophagy-mediated protein degradation. These
studies extend the interaction between viruses and their hosts and show a
co-evolved balance during the long-term “arms race” between plants and viruses,
which provides new insight into plant defenses against geminivirus–betasatellite
complexes and viral counterdefense measures.
What advice do you have for
young scientists aspiring to achieve the level of science that has major
impact?
First
of all, focus on scientific questions that exist in nature. Second, pursue your
goal and finish your project with careful study and deep consideration. As
science and technology develop very fast, you need to apply different knowledge
and methods from cross-disciplinary fields into your profession.
When you were a post-doc,
what had the largest influence on your decision to enter your specific research
area in your permanent position? Was this a “hot topic” at the time, or did you
choose to go in a different direction?
Since
finishing my post-doc, I have been working on plant–virus interaction using
geminiviruses. The main reason I decided to work on this specific research is
the serious threat of geminiviruses in crops in China. We have been committed
to understanding the pathogenic mechanisms of geminiviruses, exploring and
exploiting valuable resistance strategies against geminivirus infection. It is
a hot topic in the field of plant virology. We noticed that viruses led to a
large loss in rice yields. Therefore, now we also work on interaction between the
plant and the rice stripe virus.
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